Selected Publications

(For all publications, please go to https://scholar.google.com/citations?user=0PFlSt4AAAAJ&hl=en)

Song LS, Hall DD, Wang J. Calpain cleavage of Junctophilin-2 during cardiac stress: The G482/T483 site is not to be blamed. J Mol Cell Cardiol. 2024 Dec 15: S0022-2828(24)00210-4. doi: 10.1016/j.yjmcc.2024.12.005. Online ahead of print. PMID: 39689835. 

Wang J, Chen B, Shi Q, Ciampa G, Zhao W, Zhang G, Weiss RM, Peng T, Hall DD, Song LS. Preventing Site-Specific Calpain Proteolysis of Junctophilin-2 Protects Against Stress-Induced Excitation-Contraction Uncoupling and Heart Failure Development. Circulation. 2024 Sep 18. doi: 10.1161/CIRCULATIONAHA.124.069329.

Shi Q,* Wang J, Malik H, Li X, Streeter J, Sharafuddin J, Weatherford E, Stein D, Itan Y, Chen B, Hall D, Song LS,* Abel ED.* IRS2 Signaling Protects Against Stress-Induced Arrhythmia by Maintaining Ca²⁺ Homeostasis. Circulation. 2024 Dec 10;150(24):1966-1983. doi: 10.1161/CIRCULATIONAHA.123.065048. Epub 2024 Sep 10. PMID: 39253856 (*, Q. Shi, L.-S. Song, and E.D. Abel contributed equally).

Wang Q, Yuan J, Shen H, Zhu Q, Chen B, Wang J, Zhu W, Yorek MA, Hall DD, Wang Z, Song LS. Calpain inhibition protects against atrial fibrillation by mitigating diabetes-associated atrial fibrosis and calcium handling dysfunction in type 2 diabetes mice. Heart Rhythm. 2024 Jul;21(7):1143-1151. doi: 10.1016/j.hrthm.2024.02.036.

Xu C, Zhang G, Wang X, Huang X, Zhang J, Han S, Wang J, Hall DD, Xu R, He F, Chang X, Wang F, Xie W, Wu Z, Song LS, Han P. Ptpn23 Controls Cardiac T-Tubule Patterning by Promoting the Assembly of Dystrophin-Glycoprotein Complex. Circulation. 2024 Apr 23;149(17):1375-1390. doi: 10.1161/CIRCULATIONAHA.123.065767. 

Hall DD, Takeshima H, Song LS. Structure, Function, and Regulation of the Junctophilin Family. Annu Rev Physiol. 2024 Feb 12;86:123-147. doi: 10.1146/annurev-physiol-042022-014926.

Wang Y, Wang J, Shi L, Chen X, Li D, Cui C, Yang K, Lu M, Huang J, Zhang L, Li F, Wang J, Chen B, Wang B, Hall DD, Pan Z, Hong J, Song LS * (lead contact), Song L*, Zhao S*. CIB2 Is a Novel Endogenous Repressor of Atrial Remodeling. Circulation. 2023 Jun 6;147(23):1758-1776. doi: 10.1161/CIRCULATIONAHA.122.062660. 

Hall DD, Shi Q, Song LS. Prohibiting MG53 Phosphorylation Optimizes its Therapeutic Potential in Diabetes. Circ Res. 2022 Dec 2;131(12):977-979. doi: 10.1161/CIRCRESAHA.122.322132.

Shi Q, Hall DD, Song LS. A Ca²⁺ cycling defect connects insulin resistance and heart failure. Life Metab. 2022 Aug;1(1):2-3. doi: 10.1093/lifemeta/loac014. 

Wang J, Shi Q, Wang Y, Dawson LW, Ciampa G, Zhao W, Zhang G, Chen B, Weiss RM, Grueter CE, Hall DD, Song LS. Gene Therapy With the N-Terminus of Junctophilin-2 Improves Heart Failure in Mice. Circ Res. 2022 Mar 23;CIRCRESAHA121320680. doi: 10.1161/CIRCRESAHA.121.320680.

Wang J, Ciampa G, Zheng D, Shi Q, Chen B, Abel ED, Peng T, Hall DD, Song LS. Calpain-2 specifically cleaves Junctophilin-2 at the same site as Calpain-1 but with less efficacy. Biochem J. 2021 Oct 15;478(19):3539-3553. doi: 10.1042/BCJ20210629.

Wang J, Hall DD, Song LS. Nexilin is a New Player for Shaping T-Tubules in Cardiomyocytes. Circ Heart Fail. 2020 Jul, 13(7):e007196. doi: 10.1161 (Invited Editorial). 

Wang Y, Li C, Shi L, Chen X, Cui C, Huang J, Chen B,  Hall DD, Pan Z, Lu M, Hong J, Song LS* (lead contact), Zhao S*. Integrin β1D Deficiency-Mediated RyR2 Dysfunction Contributes to Catecholamine-Sensitive Ventricular Tachycardia in Arrhythmogenic Right Ventricular Cardiomyopathy. Circulation. 2020 May 5;141(18):1477-1493.doi: 10.1161/CIRCULATIONAHA.119.043504. 

Guo A, Wang Y, Chen B, Wang Y, Yuan J, Zhang L, Hall D, Wu J, Shi Y, Zhu Q, Chen C, Thiel WH, Zhan X, Weiss RM, Zhan F, Musselman CA, Pufall M, Zhu W, Au KF, Hong J, Anderson ME, Grueter CE, Song LS. E-C coupling structural protein junctophilin-2 encodes a stress-adaptive transcription regulator. Science. 2018 Dec 21;362(6421). pii: eaan3303. doi: 10.1126/science.aan3303. 

• Comment in: Padmanabhan A, Haldar SM. Unusual transcription factor protects against heart failure. Science. 2018 Dec 21;362(6421):1359-1360. doi: 10.1126/science.aav8956.
• Highlight in: Lim GB. Protective transcriptional repression by junctophilin 2 fragment. Nat Rev Cardiol. 2019 Jan;16(1):5. doi: 10.1038/s41569-018-0130-9.

Wang Y, Chen B, Huang CK, Guo A, Wu J, Zhang X, Chen R, Chen C, Kutschke W, Weiss RM, Boudreau RL, Margulies KB, Hong J, Song LS. Targeting Calpain for Heart Failure Therapy: Implications From Multiple Murine Models. JACC Basic Transl Sci. 2018 Aug 28;3(4):503-517. doi: 10.1016/j.jacbts.2018.05.004.

Yan J, Zhao W, Thomson JK, Gao X, DeMarco DM, Carrillo E, Chen B, Wu X, Ginsburg KS, Bakhos M, Bers DM, Anderson ME, Song LS, Fill M, Ai X. Stress Signaling JNK2 Crosstalk with CaMKII Underlies Enhanced Atrial Arrhythmogenesis. Circ Res. 2018 Jan 19. pii: CIRCRESAHA.117.312536. doi: 10.1161/CIRCRESAHA.117.312536. 

Guo A, Chen R, Wang Y, Huang CK, Chen B, Kutschke W, Hong J, Song LS. Transient activation of PKC results in long-lasting detrimental effects on systolic [Ca²⁺]_i in cardiomyocytes by altering actin cytoskeletal dynamics and T-tubule integrity. J Mol Cell Cardiol. 2018 Jan 4. pii: S0022-2828(18)30012-9. doi: 10.1016/j.yjmcc.2018.01.003. 

Zhang C, Chen B, Wang Y, Guo A, Tang Y, Khataei T, Shi Y, Kutschke WJ, Zimmerman K, Weiss RM, Liu J, Benson CJ, Hong J, Ma J, Song LS. MG53 is dispensable for T-tubule maturation but critical for maintaining T-tubule integrity following cardiac stress. J Mol Cell Cardiol. 2017 Aug 16. pii: S0022-2828(17)30288-2. doi: 10.1016/j.yjmcc.2017.08.007. 

Hall DD, Ponce JM, Chen B, Spitler KM, Alexia A, Oudit GY, Song LS, Grueter CE. Ectopic expression of Cdk8 induces eccentric hypertrophy and heart failure. JCI Insight. 2017 Aug 3;2(15). pii: 92476. doi: 10.1172/jci.insight.92476. 

Guo Y, VanDusen NJ, Zhang L, Gu W, Sethi I, Guatimosim S, Ma Q, Jardin BD, Ai Y, Zhang D, Chen B, Guo A, Yuan GC, Song LS, Pu WT. Analysis of Cardiac Myocyte Maturation Using CASAAV, a Platform for Rapid Dissection of Cardiac Myocyte Gene Function In Vivo. Circ Res. 2017 Jun 9;120(12):1874-1888. doi: 10.1161/CIRCRESAHA.116.310283. Review.

Zhong X, Sun B, Vallmitjana A, Mi T, Guo W, Ni M, Wang R, Guo A, Duff HJ, Gillis AM, Song LS, Hove-Madsen L, Benitez R, Chen SR. Suppression of ryanodine receptor function prolongs Ca²⁺ release refractoriness and promotes cardiac alternans in intact hearts. Biochem J. 2016 Nov 1;473(21):3951-3964. 

Zhu Y, Zhang C, Chen B, Chen R, Guo A, Hong J, Song LS. Cholesterol is required for maintaining T-tubule integrity and intercellular connections at intercalated discs in cardiomyocytes. J Mol Cell Cardiol. 2016 Aug;97:204-12. doi: 10.1016/j.yjmcc.2016.05.013. 

Guo A, Hall D, Zhang C, Peng T, Miller JD, Kutschke W, Grueter CE, Johnson FL, Lin RZ, Song LS. Molecular Determinants of Calpain-dependent Cleavage of Junctophilin-2 Protein in Cardiomyocytes. J Biol Chem. 2015 Jul 17;290(29):17946-55. doi: 10.1074/jbc.M115.652396. 

Chen B, Zhang C, Guo A, Song LS. In situ single photon confocal imaging of cardiomyocyte T-tubule system from Langendorff-perfused hearts. Front Physiol. 2015 May 6;6:134. doi: 10.3389/fphys.2015.00134. eCollection 2015. Review.

Takeshima H, Hoshijima M, Song LS. Ca²⁺ microdomains organized by junctophilins. Cell Calcium. 2015 Oct;58(4):349-56. doi: 10.1016/j.ceca.2015.01.007. Review.

Guo A, Zhang X, Iyer VR, Chen B, Zhang C, Kutschke WJ, Weiss RM, Franzini-Armstrong C, Song LS. Overexpression of junctophilin-2 does not enhance baseline function but attenuates heart failure development after cardiac stress. Proc Natl Acad Sci USA. 2014 Aug 19;111(33):12240-5. doi: 10.1073/pnas.1412729111. 

Wu CY, Chen B, Jiang YP, Jia Z, Martin DW, Liu S, Entcheva E, Song LS, Lin RZ. Calpain-dependent cleavage of junctophilin-2 and T-tubule remodeling in a mouse model of reversible heart failure. J Am Heart Assoc. 2014 Jun 23;3(3):e000527. doi: 10.1161/JAHA.113.000527.

Guo A, Song LS. AutoTT: automated detection and analysis of T-tubule architecture in cardiomyocytes. Biophys J. 2014 Jun 17;106(12):2729-36. doi: 10.1016/j.bpj.2014.05.013.

Zhang C, Chen B, Guo A, Zhu Y, Miller JD, Gao S, Yuan C, Kutschke W, Zimmerman K, Weiss RM, Wehrens XH, Hong J, Johnson FL, Santana LF, Anderson ME, Song LS. Microtubule-mediated defects in junctophilin-2 trafficking contribute to myocyte transverse-tubule remodeling and Ca²⁺ handling dysfunction in heart failure. Circulation. 2014 Apr 29;129(17):1742-50. doi: 10.1161/CIRCULATIONAHA.113.008452. 

Chen W, Wang R, Chen B, Zhong X, Kong H, Bai Y, Zhou Q, Xie C, Zhang J, Guo A, Tian X, Jones PP, O'Mara ML, Liu Y, Mi T, Zhang L, Bolstad J, Semeniuk L, Cheng H, Zhang J, Chen J, Tieleman DP, Gillis AM, Duff HJ, Fill M, Song LS, Chen SR. The ryanodine receptor store-sensing gate controls Ca²⁺ waves and Ca²⁺-triggered arrhythmias. Nat Med. 2014 Feb;20(2):184-92. doi: 10.1038/nm.3440. 

Chen B, Guo A, Zhang C, Chen R, Zhu Y, Hong J, Kutschke W, Zimmerman K, Weiss RM, Zingman L, Anderson ME, Wehrens XH, Song LS. Critical roles of junctophilin-2 in T-tubule and excitation-contraction coupling maturation during postnatal development. Cardiovasc Res. 2013 Oct 1;100(1):54-62. doi: 10.1093/cvr/cvt180.

Guo A, Zhang C, Wei S, Chen B, Song LS. Emerging mechanisms of T-tubule remodelling in heart failure. Cardiovasc Res. 2013 May 1;98(2):204-15. doi: 10.1093/cvr/cvt020. Review.

Joiner ML, Koval OM, Li J, He BJ, Allamargot C, Gao Z, Luczak ED, Hall DD, Fink BD, Chen B, Yang J, Moore SA, Scholz TD, Strack S, Mohler PJ, Sivitz WI, Song LS, Anderson ME. CaMKII determines mitochondrial stress responses in heart. Nature. 2012 Nov 8;491(7423):269-73. doi: 10.1038/nature11444. 

Chen B, Guo A, Gao Z, Wei S, Xie YP, Chen SR, Anderson ME, Song LS. In situ confocal imaging in intact heart reveals stress-induced Ca²⁺ release variability in a murine catecholaminergic polymorphic ventricular tachycardia model of type 2 ryanodine receptor(R4496C+/-) mutation. Circ Arrhythm Electrophysiol. 2012 Aug 1;5(4):841-9. doi: 10.1161/CIRCEP.111.969733. 

Guo A, Cala SE, Song LS. Calsequestrin accumulation in rough endoplasmic reticulum promotes perinuclear Ca²⁺ release. J Biol Chem. 2012 May 11;287(20):16670-80. doi: 10.1074/jbc.M112.340927.

Chen B, Li Y, Jiang S, Xie YP, Guo A, Kutschke W, Zimmerman K, Weiss RM, Miller FJ, Anderson ME, Song LS. β-Adrenergic receptor antagonists ameliorate myocyte T-tubule remodeling following myocardial infarction. FASEB J. 2012 Jun;26(6):2531-7. doi: 10.1096/fj.11-199505. 

Xie YP, Chen B, Sanders P, Guo A, Li Y, Zimmerman K, Wang LC, Weiss RM, Grumbach IM, Anderson ME, Song LS. Sildenafil prevents and reverses transverse-tubule remodeling and Ca²⁺ handling dysfunction in right ventricle failure induced by pulmonary artery hypertension. Hypertension. 2012 Feb;59(2):355-62. doi: 10.1161/HYPERTENSIONAHA.111.180968. 

Guatimosim S, Guatimosim C, Song LS. Imaging calcium sparks in cardiac myocytes. Methods Mol Biol. 2011;689:205-14. doi: 10.1007/978-1-60761-950-5_12.

Wei S, Guo A, Chen B, Kutschke W, Xie YP, Zimmerman K, Weiss RM, Anderson ME, Cheng H, Song LS. T-tubule remodeling during transition from hypertrophy to heart failure. Circ Res. 2010 Aug 20;107(4):520-31. doi: 10.1161/CIRCRESAHA.109.212324. 

Chen B, Wu Y, Mohler PJ, Anderson ME, Song LS. Local control of Ca²⁺-induced Ca²⁺ release in mouse sinoatrial node cells. J Mol Cell Cardiol. 2009 Nov;47(5):706-15. doi: 10.1016/j.yjmcc.2009.07.007.

Wu Y, Gao Z, Chen B, Koval OM, Singh MV, Guan X, Hund TJ, Kutschke W, Sarma S, Grumbach IM, Wehrens XH, Mohler PJ, Song LS, Anderson ME. Calmodulin kinase II is required for fight or flight sinoatrial node physiology. Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5972-7. doi: 10.1073/pnas.0806422106.

Wei C, Wang X, Chen M, Ouyang K, Song LS, Cheng H. Calcium flickers steer cell migration. Nature. 2009 Feb 12;457(7231):901-5. doi: 10.1038/nature07577. 

Song LS, Sobie EA, McCulle S, Lederer WJ, Balke CW, Cheng H. Orphaned ryanodine receptors in the failing heart. Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4305-10. doi: 10.1073/pnas.0509324103.