Publications

Selected Publications

Gene Therapy With the N-Terminus of Junctophilin-2 Improves Heart Failure in Mice. Wang J, Shi Q, Wang Y, Dawson LW, Ciampa G, Zhao W, Zhang G, Chen B, Weiss RM, Grueter CE, Hall DD, Song LS. Circ Res. 2022 Mar 23;CIRCRESAHA121320680. doi: 10.1161/CIRCRESAHA.121.320680.

Calpain-2 specifically cleaves Junctophilin-2 at the same site as Calpain-1 but with less efficacy. Wang J, Ciampa G, Zheng D, Shi Q, Chen B, Abel ED, Peng T, Hall DD, Song LS. Biochem J. 2021 Oct 15;478(19):3539-3553. doi: 10.1042/BCJ20210629.

Nexilin is a New Player for Shaping T-Tubules in Cardiomyocytes. Wang J, Hall DD, Song LS. Circ Heart Fail. 2020 Jul, 13(7):e007196. doi: 10.1161 (Invited Editorial).

Integrin β1D Deficiency-Mediated RyR2 Dysfunction Contributes to Catecholamine-Sensitive Ventricular Tachycardia in Arrhythmogenic Right Ventricular Cardiomyopathy. Wang Y, Li C, Shi L, Chen X, Cui C, Huang J, Chen B, Hall DD, Pan Z, Lu M, Hong J, Song LS* (lead contact), Zhao S*. Circulation. 2020 May 5;141(18):1477-1493.doi: 10.1161/CIRCULATIONAHA.119.043504. Epub 2020 Mar 3.

E-C coupling structural protein junctophilin-2 encodes a stress-adaptive transcription regulator. Guo A, Wang Y, Chen B, Wang Y, Yuan J, Zhang L, Hall D, Wu J, Shi Y, Zhu Q, Chen C, Thiel WH, Zhan X, Weiss RM, Zhan F, Musselman CA, Pufall M, Zhu W, Au KF, Hong J, Anderson ME, Grueter CE, Song LS. Science. 2018 Dec 21;362(6421). pii: eaan3303. doi: 10.1126/science.aan3303. Epub 2018 Nov 8. PMID:30409805

Stress Signaling JNK2 Crosstalk with CaMKII Underlies Enhanced Atrial Arrhythmogenesis. Yan J, Zhao W, Thomson JK, Gao X, DeMarco DM, Carrillo E, Chen B, Wu X, Ginsburg KS, Bakhos M, Bers DM, Anderson ME, Song LS, Fill M, Ai X. Circ Res. 2018 Jan 19. pii: CIRCRESAHA.117.312536. doi: 10.1161/CIRCRESAHA.117.312536. [Epub ahead of print]

Transient activation of PKC results in long-lasting detrimental effects on systolic [Ca²⁺]_i in cardiomyocytes by altering actin cytoskeletal dynamics and T-tubule integrity. Guo A, Chen R, Wang Y, Huang CK, Chen B, Kutschke W, Hong J, Song LS. J Mol Cell Cardiol. 2018 Jan 4. pii: S0022-2828(18)30012-9. doi: 10.1016/j.yjmcc.2018.01.003. [Epub ahead of print]

MG53 is dispensable for T-tubule maturation but critical for maintaining T-tubule integrity following cardiac stress. Zhang C, Chen B, Wang Y, Guo A, Tang Y, Khataei T, Shi Y, Kutschke WJ, Zimmerman K, Weiss RM, Liu J, Benson CJ, Hong J, Ma J, Song LS. J Mol Cell Cardiol. 2017 Aug 16. pii: S0022-2828(17)30288-2. doi: 10.1016/j.yjmcc.2017.08.007. [Epub ahead of print]

Ectopic expression of Cdk8 induces eccentric hypertrophy and heart failure. Hall DD, Ponce JM, Chen B, Spitler KM, Alexia A, Oudit GY, Song LS, Grueter CE. JCI Insight. 2017 Aug 3;2(15). pii: 92476. doi: 10.1172/jci.insight.92476. [Epub ahead of print]

Analysis of Cardiac Myocyte Maturation Using CASAAV, a Platform for Rapid Dissection of Cardiac Myocyte Gene Function In Vivo. Guo Y, VanDusen NJ, Zhang L, Gu W, Sethi I, Guatimosim S, Ma Q, Jardin BD, Ai Y, Zhang D, Chen B, Guo A, Yuan GC, Song LS, Pu WT. Circ Res. 2017 Jun 9;120(12):1874-1888. doi: 10.1161/CIRCRESAHA.116.310283. Epub 2017 Mar 29. Review.

Suppression of ryanodine receptor function prolongs Ca2+ release refractoriness and promotes cardiac alternans in intact hearts. Zhong X, Sun B, Vallmitjana A, Mi T, Guo W, Ni M, Wang R, Guo A, Duff HJ, Gillis AM, Song LS, Hove-Madsen L, Benitez R, Chen SR. Biochem J. 2016 Nov 1;473(21):3951-3964. Epub 2016 Aug 31.

Cholesterol is required for maintaining T-tubule integrity and intercellular connections at intercalated discs in cardiomyocytes. Zhu Y, Zhang C, Chen B, Chen R, Guo A, Hong J, Song LS. J Mol Cell Cardiol. 2016 Aug;97:204-12. doi: 10.1016/j.yjmcc.2016.05.013. Epub 2016 May 30.

Molecular Determinants of Calpain-dependent Cleavage of Junctophilin-2 Protein in Cardiomyocytes. Guo A, Hall D, Zhang C, Peng T, Miller JD, Kutschke W, Grueter CE, Johnson FL, Lin RZ, Song LS. J Biol Chem. 2015 Jul 17;290(29):17946-55. doi: 10.1074/jbc.M115.652396. Epub 2015 Jun 10.

In situ single photon confocal imaging of cardiomyocyte T-tubule system from Langendorff-perfused hearts. Chen B, Zhang C, Guo A, Song LS. Front Physiol. 2015 May 6;6:134. doi: 10.3389/fphys.2015.00134. eCollection 2015. Review.

Ca²⁺ microdomains organized by junctophilins. Takeshima H, Hoshijima M, Song LS. Cell Calcium. 2015 Oct;58(4):349-56. doi: 10.1016/j.ceca.2015.01.007. Epub 2015 Jan 25. Review.

Overexpression of junctophilin-2 does not enhance baseline function but attenuates heart failure development after cardiac stress. Guo A, Zhang X, Iyer VR, Chen B, Zhang C, Kutschke WJ, Weiss RM, Franzini-Armstrong C, Song LS. Proc Natl Acad Sci USA. 2014 Aug 19;111(33):12240-5. doi: 10.1073/pnas.1412729111. Epub 2014 Aug 4.

Calpain-dependent cleavage of junctophilin-2 and T-tubule remodeling in a mouse model of reversible heart failure. Wu CY, Chen B, Jiang YP, Jia Z, Martin DW, Liu S, Entcheva E, Song LS, Lin RZ. J Am Heart Assoc. 2014 Jun 23;3(3):e000527. doi: 10.1161/JAHA.113.000527.

AutoTT: automated detection and analysis of T-tubule architecture in cardiomyocytes. Guo A, Song LS. Biophys J. 2014 Jun 17;106(12):2729-36. doi: 10.1016/j.bpj.2014.05.013.

Microtubule-mediated defects in junctophilin-2 trafficking contribute to myocyte transverse-tubule remodeling and Ca2+ handling dysfunction in heart failure. Zhang C, Chen B, Guo A, Zhu Y, Miller JD, Gao S, Yuan C, Kutschke W, Zimmerman K, Weiss RM, Wehrens XH, Hong J, Johnson FL, Santana LF, Anderson ME, Song LS. Circulation. 2014 Apr 29;129(17):1742-50. doi: 10.1161/CIRCULATIONAHA.113.008452. Epub 2014 Feb 11.

The ryanodine receptor store-sensing gate controls Ca2+ waves and Ca2+-triggered arrhythmias. Chen W, Wang R, Chen B, Zhong X, Kong H, Bai Y, Zhou Q, Xie C, Zhang J, Guo A, Tian X, Jones PP, O'Mara ML, Liu Y, Mi T, Zhang L, Bolstad J, Semeniuk L, Cheng H, Zhang J, Chen J, Tieleman DP, Gillis AM, Duff HJ, Fill M, Song LS, Chen SR. Nat Med. 2014 Feb;20(2):184-92. doi: 10.1038/nm.3440. Epub 2014 Jan 19.

Emerging mechanisms of T-tubule remodelling in heart failure. Guo A, Zhang C, Wei S, Chen B, Song LS. Cardiovasc Res. 2013 May 1;98(2):204-15. doi: 10.1093/cvr/cvt020. Epub 2013 Feb 7. Review.

CaMKII determines mitochondrial stress responses in heart. Joiner ML, Koval OM, Li J, He BJ, Allamargot C, Gao Z, Luczak ED, Hall DD, Fink BD, Chen B, Yang J, Moore SA, Scholz TD, Strack S, Mohler PJ, Sivitz WI, Song LS, Anderson ME. Nature. 2012 Nov 8;491(7423):269-73. doi: 10.1038/nature11444. Epub 2012 Oct 10.

In situ confocal imaging in intact heart reveals stress-induced Ca(2+) release variability in a murine catecholaminergic polymorphic ventricular tachycardia model of type 2 ryanodine receptor(R4496C+/-) mutation. Chen B, Guo A, Gao Z, Wei S, Xie YP, Chen SR, Anderson ME, Song LS. Circ Arrhythm Electrophysiol. 2012 Aug 1;5(4):841-9. doi: 10.1161/CIRCEP.111.969733. Epub 2012 Jun 21.

Calsequestrin accumulation in rough endoplasmic reticulum promotes perinuclear Ca2+ release. Guo A, Cala SE, Song LS. J Biol Chem. 2012 May 11;287(20):16670-80. doi: 10.1074/jbc.M112.340927. Epub 2012 Mar 28.

β-Adrenergic receptor antagonists ameliorate myocyte T-tubule remodeling following myocardial infarction. Chen B, Li Y, Jiang S, Xie YP, Guo A, Kutschke W, Zimmerman K, Weiss RM, Miller FJ, Anderson ME, Song LS. FASEB J. 2012 Jun;26(6):2531-7. doi: 10.1096/fj.11-199505. Epub 2012 Feb 28.

Sildenafil prevents and reverses transverse-tubule remodeling and Ca(2+) handling dysfunction in right ventricle failure induced by pulmonary artery hypertension. Xie YP, Chen B, Sanders P, Guo A, Li Y, Zimmerman K, Wang LC, Weiss RM, Grumbach IM, Anderson ME, Song LS. Hypertension. 2012 Feb;59(2):355-62. doi: 10.1161/HYPERTENSIONAHA.111.180968. Epub 2011 Dec 27.

T-tubule remodeling during transition from hypertrophy to heart failure. Wei S, Guo A, Chen B, Kutschke W, Xie YP, Zimmerman K, Weiss RM, Anderson ME, Cheng H, Song LS. Circ Res. 2010 Aug 20;107(4):520-31. doi: 10.1161/CIRCRESAHA.109.212324. Epub 2010 Jun 24.